This article is about the explanation of mRNA vaccines, usefulness, good and bad points, and application. You don't need to be a medial specialist or doctor to understand what a mRNA vaccine is, what its good and bad points are. This article is good for those who are considering to take the mRNA vaccine or not. This article has two parts. The first part explaining the mRNA vaccine scientifically and the second part is the explanation in plain English.

(At the end of this article is the plain English version)

Inside our cells, the DNA sequences that hold the instructions for each of the roughly 20,000 protein-coding genes in the human genome are safely sequestered inside a cell’s nucleus for protection. These sequences of nucleotides that make up our genes hold the blueprints for building proteins, the long chains of amino acids that perform the basic functions of life inside a cell, including DNA replication, responding to stimuli, transporting molecules, performing metabolic activities and building cell structures.

Because DNA is so fragile and important, however, an intermediary needs to move this information from the nucleus of the cell, where the genome resides, to the cytoplasm, where the amino acids and molecules that are the building blocks to make these proteins are found.

Messenger RNAs (mRNA) are the set of protein-building instructions that can move from the nucleus of the cell to the cytoplasm. mRNAs are created as an exact copy of the segment of DNA found along the genome corresponding to a protein-coding gene. Unlike DNA, the mRNA can move from the cell’s nucleus to the cytoplasm. Once inside the cell’s cytoplasm, the machinery responsible for building proteins, called the ribosome, reads the mRNA and gets to work making proteins. After the mRNA is read and the building process begins, the mRNA is quickly destroyed by the cell. Destruction of the mRNA ensures that the cell does not make too much of one type of protein.

Scientists are using the mRNA process to develop vaccines against viruses such as SARS-CoV-2. When a virus infects a cell, it uses the cell’s protein-making machinery to make its own proteins instead of the cell’s proteins. It then uses these viral proteins to make more of itself, replicate and infect even more cells. The immune system is designed to recognize these foreign proteins, wake up and defend itself.

The idea behind mRNA vaccines, like the kind developed by Moderna and Pfizer for COVID-19, is to insert an mRNA from the virus into a cell. The cell would then turn this mRNA into a viral protein. A single viral protein would not be enough to cause the cell harm or the host to become sick. Given the right mRNA and the right protein, however, it may activate the immune response.

In this case, the immune system could begin mounting a response and deploying antibodies against the virus without being infected. The body would then be able to easily fight off any subsequent infection quickly because antibodies are already present, eliminating or mitigating the severity of the illness.

To repeat this in plain English

Before explaining how mRNA vaccines work, first let's explain what a vaccine actually is. Why? Because we can assume that the mRNA suppose to work like a vaccine (while it actually not is).

Vaccine vs. mRNA vaccine

A vaccine is weakened or killed forms of the microbe (i.e. virus) that provides active acquired immunity to a particular infectious disease (i.e. Avian flu).

The mRNA vaccine is not a real vaccine! That said, this is how a real vaccine works:

After the immune system of a host (a person or animal) is vaccinated with the (normal) vaccine, the immune system knows how to recognize the virus. When it detects the virus, it attacks and kills the virus the moment it enters the body.

The mRNA is doing that differently. When (only) the COVID-19 virus enters the body of the host, the immune system will not attack and kill the virus. The virus will look for a cell in order to duplicate itself. In order to do that, it will try to penetrate a cell and here the mRNA vaccine will interfere and make it impossible to do that.

Does the mRNA vaccine protect you from the COVID-19?

Yes and no.

Because the COVID-19 virus can not grow in your body when you are vaccinated with the mRNA vaccine, it doesn't make you sick (most cases). This is the only form of protection you have with the mRNA vaccine. And it's perfect for elderly and those with serious underlying diseases and with a weak immune system.

But that doesn't mean that it prevents the COVID-19 virus from entering your body. It also doesn't prevent your body to infect others.

The mRNA vaccine is perfect designed for elderly, seriously sick and with immunity problems, but it's not useful for those who are healthy, whatever the age.

Side effects, health problems and even death

Both the conventional vaccines and the mRNA vaccine cause problems (serious side effects and even death) to a certain number of people (mostly a few percentages or even less). That's a given when you take the risk of having a vaccine.

Also, vaccines do not always work for everyone. Each body of any host is unique. But also here it will not work for a certain number of people and mostly a few percentages of the total.

Reasons to take the mRNA vaccine

Especially today, the pressure of the authorities (and partly peer pressure as well), and schools and employers would or might influence you to take the mRNA vaccine after all. Don't give in and first think about it.

Reasons why you should take the mRNA vaccine

1. You suffer from serious sickness, it's a good idea to take the mRNA vaccine without doubt.

2. You have problems with your immunity. Also here it's strongly advised to take the mRNA vaccine.

3. You might be obese. Consider to take the mRNA vaccine.

• Actually, if you suffer from any serious medical ailment, consider to take the vaccine.

• If your employer is trying to force you to take the vaccine, and you don't have any other options, consider to take the mRNA vaccine.

• If your school, university or any other educational institute try to force you, refuse the mRNA vaccine and find another institute.

• Be aware, even when you have taken all the COVID-19 jabs, you still can get infected and you still can infect others.

Reasons for refusing the mRNA vaccine

1. When you are healthy, whatever the age, refuse the mRNA vaccine.

   1. You might get infected with the COVID-19 virus, but you'll not die from it.

   2. 30% of all infections of healthy people don't show any symptoms.

   3. After a few days the infection is gone.

   4. You are truly immune for a very long time against COVID-19.

2. Don't play Russian roulette with your health (or that from your children and others)

   1. With this game of chance, you take the risk to be killed.

   2. The same as with taking the COVID-19 vaccine. You take the risk to be killed or permanently hurt.

• If a government tries to refuse services to those who are unvaccinated, that is in any democracy illegal.

  • It's a question of time that the government will be stopped (i.e. high court).

  • Some governments are threatening with those measures, but until now none of them have this implemented. They know they can't do this, because it's illegal.

• This actually applies for any (real) vaccine. If the risk is simply too low (like with COVID-19), refuse the vaccine.

Respect your community and trust

If you live in a community, where the majority (or just a few) have been vaccinated, respect their choices and accept also the restrictions like face mask and social distancing.

With the obvious attempts of authorities and media to push certain health related policies you don't agree with (like the vaccinations), and you don't trust them, and you're healthy, refuse vaccinations and ignore them. There are too many issues related with the corona and the vaccines to give trust in those sources.